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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-LIM Kinase (LIMK)-SM311
SM311

Chemical Structure : SM311

CAS No.:

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SM311 (SM-311)

货号: PC-26187Not For Human Use, Lab Use Only.

SM311 is a potent, selective, covalent LIMK1 inhibitor with EC50 of 45 nM in NanoBRET assays, 150-fold selective over LIMK2 isoform.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SM311 is a potent, selective, covalent LIMK1 inhibitor with EC50 of 45 nM in NanoBRET assays, 150-fold selective over LIMK2 isoform.
SM311 (100 nM) induces suppression of cofilin phosphorylation in LN229 glioblastoma cells.
SM311 displays excellent proteome-wide selectivity in pull-down assays.

物理化学性质&存储条件

分子量 431.46
分子式 C20H19F2N5O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-(3-(difluoromethyl)-5-(2-isobutyramidothiazol-5-yl)-1H-pyrazol-1-yl)phenyl)acrylamide

参考文献

1. Mandel S, et al. bioRxiv, 2025: 2025.04. 17.649341.

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