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首页-小分子抑制剂&激动剂-NF-κB Pathway-NF-κB-SM-7368
SM-7368

Chemical Structure : SM-7368

CAS No.: 380623-76-7

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SM-7368 (SM7368)

货号: PC-24658Not For Human Use, Lab Use Only.

SM-7368 is a small molecule NF-kB inhibitor, inhibits TNF-alpha-induced MMP-9 upregulation, strongly inhibits TNF-alpha-induced NF-kappaB activity but not AP-1 activity.

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10 mg ￥780 In stock
25 mg ￥1180 In stock
50 mg ￥1880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SM-7368 is a small molecule NF-kB inhibitor, inhibits TNF-alpha-induced MMP-9 upregulation, strongly inhibits TNF-alpha-induced NF-kappaB activity but not AP-1 activity.
SM-7368 strongly inhibits the TNF-alpha-induced invasion of HT1080 human fibrosarcoma cell line.

物理化学性质&存储条件

分子量 328.68
分子式 C10H5ClN4O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Chloro-4-nitro-N-(5-nitrothiazol-2-yl)benzamide

参考文献

1. Lee HY, et al. Biochem Biophys Res Commun. 2005 Oct 21;336(2):716-22.

2. Samuel T, et al. BMC Cancer. 2014 Aug 18;14:599.

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