SM-368229 (SM368229)

Chemical Structure : SM-368229

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货号: PC-25374Not For Human Use, Lab Use Only.

SM-368229 is a potent, selective mineralocorticoid receptor (MR) antagonist with IC50 of 21 and 120 nM in binding assay and reporter-gene assay, respectively.

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100 mg		Get quote

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生物&药学活性

SM-368229 is a potent, selective mineralocorticoid receptor (MR) antagonist with IC50 of 21 and 120 nM in binding assay and reporter-gene assay, respectively.
SM-368229 is 18-fold selective over other steroid receptors, such as androgen, progesterone, and glucocorticoid receptors.
SM-368229 dose-dependently increased urinary Na+/K+ ratio with an ED50 value of 5.6 mg/kg in adrenalectomized rats treated with deoxycorticosterone acetate.

物理化学性质&存储条件

分子量	354.46
分子式	C14H14N2O3S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4,4-dimethyl-2-thioxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)thiophene-2-sulfonamide

参考文献

1. Nariai T, et al. J Pharmacol Sci. 2011;115(3):346-53.