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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Wnt-SLD1121
SLD1121

Chemical Structure : SLD1121

CAS No.: 2759011-75-9

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SLD1121 (SLD-1121)

货号: PC-26107Not For Human Use, Lab Use Only.

SLD1121(SLD-1121) is a small molecule agonist of Wnt/β-catenin signaling pathway with EC50 of 0.21 uM for LRP6-mediated Wnt activation, interacts with the intracellular domain of LRP6 (Kd=7.49 nM, LRP6-ICD domain), stabilizes LRP6, and accelerates its nuclear translocation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SLD1121(SLD-1121) is a small molecule agonist of Wnt/β-catenin signaling pathway with EC50 of 0.21 uM for LRP6-mediated Wnt activation, interacts with the intracellular domain of LRP6 (Kd=7.49 nM, LRP6-ICD domain), stabilizes LRP6, and accelerates its nuclear translocation.
SLD1121 interactes with LRP6-ICD with ITC Kd of 4.52 nM.
SLD1121 (0.125-2 uM) activates LRP6-mediated transcription in HEK293T cells.
SLD1121 (1-2 uM) upregulates the mRNA expression of Wnt target genes Axin2, LEF1, Snail1, OCT4, Twist1, Sox2, and CD44 in HaCaT cells.
SLD1121 stabilizes LRP6 through the lysosomal pathway.
SLD1121 induces the entry of LRP6 into the cell nucleus and promotes the association of LRP6 with β-catenin, promotes the association of TCF/LEF1 with the LRP6−β-catenin complex to activate the Wnt signaling pathway.
SLD1121 enhances hair regrowth in C57BL/6J mice, via the activation of Wnt/β-catenin signaling.
LRP6 is a member of the low-density lipoprotein receptor (LDLR) family, which is indispensable for Wnt signal transduction.

物理化学性质&存储条件

分子量 415.46
分子式 C26H17N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(1H-imidazo(4,5-f)(1,10)phenanthrolin-2-yl)-N-phenylbenzamide

参考文献

1. Qi Sun, et al. JACS Au. 2026 Jan 27;6(2):1256-1268.

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