SLC-391 | Axl inhibitor | Probechem Biochemicals

Chemical Structure : SLC-391

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SLC-391 (SLC391, SLC-0211)

货号: PC-24679Not For Human Use, Lab Use Only.

SLC-391 (SLC-0211) is a potent, selective small molecule inhibitor for AXL with IC50 of 9.6 nM, 4-fold selective over TYRO3 (IC=42.3 nM) and MER (IC50=44 nM).

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生物&药学活性

SLC-391 (SLC-0211) is a potent, selective small molecule inhibitor for AXL with IC50 of 9.6 nM, 4-fold selective over TYRO3 (IC=42.3 nM) and MER (IC50=44 nM).
SLC-391 demonstrates high selectivity against a panel of 93 individually expressed receptor tyrosine kinases using BaF3 cells.
SLC-391 stabilizes the AXL kinase domain, binds to its active site, and inhibits the growth of AML cells in vitro.
Dual SLC-391 and venetoclax treatment in vivo decreases leukemia burden and enhances survival of mice in 2 aggressive AML models.
Combination treatment with SLC-391 and venetoclax synergistically inhibits proliferation and long-term clonogenic activities of cells from patients with AML in vitro.
Combined treatment with SLC-391 and venetoclax decreases leukemia burden and significantly enhances survival of leukemic mice in a PDX model.

物理化学性质&存储条件

分子量	365.44
分子式	C19H23N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-(cyclopropylmethyl)-1,3,4-oxadiazole-2-yl)-5-(1-(piperidine-4-yl)-1H-pyrazole-4-yl)pyridine-2-amine

参考文献

1. Xiaojia Niu, et al. Blood. 2021 Jul 1;137(26):3641-3655.

SLC-391 (SLC391, SLC-0211)

生物&药学活性

物理化学性质&存储条件

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SLC-391 (SLC391, SLC-0211)

生物&药学活性

物理化学性质&存储条件

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