SKLB188 |CAS:1350545-09-3 Probechem Biochemicals

Chemical Structure : SKLB188

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SKLB188 (SKLB 188, SKLB-188)

货号: PC-61769Not For Human Use, Lab Use Only.

SKLB188 is a small molecule multikinase inhibitor and potently inhibits EGFR with IC50 of 5 nM.

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生物&药学活性

SKLB188 is a small molecule multikinase inhibitor and potently inhibits EGFR with IC50 of 5 nM.
SKLB188 inhibits a number of receptor tyrosine kinases, including Abl, Erb2, Erb4, Flt1, Flt3, Flt4, EphB, FGFR, c-Kit, Met, and PDGFR at 10 uM.
SKLB188 potently inhibits the growth of HNSCC cells in vitro and in vivo by targeting EGFR signalling.
SKLB188 inhibits FaDu xenograft growth in nude mice.

物理化学性质&存储条件

分子量	513.606
分子式	C27H31N9O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-cyclopentyl-N2-(4-(4-methylpiperazin-1-yl)phenyl)-N8-(3-nitrophenyl)-9H-purine-2,8-diamine

参考文献

1. Barzegar M, et al. Br J Cancer. 2017 Sep 5. doi: 10.1038/bjc.2017.298.

SKLB188 (SKLB 188, SKLB-188)

生物&药学活性

物理化学性质&存储条件

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SKLB188 (SKLB 188, SKLB-188)

生物&药学活性

物理化学性质&存储条件

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