SKL-1223 | TXNIP inhibitor | Probechem Biochemicals

Chemical Structure : SKL-1223

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SKL-1223 (SKL1223)

货号: PC-28102Not For Human Use, Lab Use Only.

SKL-1223 is an orally bioavailable small molecule inhibitor of thioredoxin-interacting protein (TXNIP) with IC50 of 0.64 uM, attenuates TXNIP transcription factor binding, promotes beta-cell formation and loss of alpha-cells, exhibits potent glucose-lowering effects in streptozotocin-induced and db/db murine models.

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生物&药学活性

SKL-1223 is an orally bioavailable small molecule inhibitor of thioredoxin-interacting protein (TXNIP) with IC50 of 0.64 uM, attenuates TXNIP transcription factor binding, promotes beta-cell formation and loss of alpha-cells, exhibits potent glucose-lowering effects in streptozotocin-induced and db/db murine models.

物理化学性质&存储条件

分子量	317.35
分子式	C19H15N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(furan-2-ylmethyl)-4-(3-phenyl-1,2,4-oxadiazol-5-yl)aniline

参考文献

1. Luo Z, et al. J Med Chem. 2026 Sep 10;69(17):20839-20858.

SKL-1223 (SKL1223)

生物&药学活性

物理化学性质&存储条件

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SKL-1223 (SKL1223)

生物&药学活性

物理化学性质&存储条件

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