SKI2852 | 11β-HSD1 inhibitor | Probechem Biochemicals

Chemical Structure : SKI2852

CAS No.: 1346554-47-9

加入收藏

SKI2852 (SKI-2852, J2H-1702)

货号: PC-61137Not For Human Use, Lab Use Only.

SKI-2852 (J2H-1702) is a highly potent, selective, and orally bioavailable 11β-HSD1 inhibitor with IC50 of 2.9 and 1.6 nM for hHSD1 and mHSD1, respectively.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3580	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SKI-2852 (J2H-1702) is a highly potent, selective, and orally bioavailable 11β-HSD1 inhibitor with IC50 of 2.9 and 1.6 nM for hHSD1 and mHSD1, respectively.
SKI-2852 demonstrates no CYP and PXR liabilities, excellent PK profiles across species, and highly potent and sustainable PD activity.
SKI-2852 significantly reduces blood glucose and HbA1c levels and improves the lipid profiles in ob/ob mice, synergistically enhances the HbA1c-lowering effect of metformin in vivo.

物理化学性质&存储条件

分子量	543.658
分子式	C27H34FN5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((R)-4-(2-Fluoro-4-(methylsulfonyl)phenyl)-2-methylpiperazin-1-yl)-N-((1R,2s,3S,5S,7S)-5-hydroxyadamantan-2-yl)pyrimidine-4-carboxamide

参考文献

1. Ryu JH, et al. J Med Chem. 2016 Nov 23;59(22):10176-10189.

SKI2852 (SKI-2852, J2H-1702)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SKI2852 (SKI-2852, J2H-1702)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.