SJ733 | PfATP4 inhibitor | Probechem Biochemicals

Chemical Structure : SJ733

CAS No.: 1424799-20-1

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SJ733 ((+)-SJ733, SJ000557733, SJ-557733)

货号: PC-61904Not For Human Use, Lab Use Only.

SJ733 (SJ000557733, SJ-557733) is an anti-malarial compound that targets ATP4 (PfATP4), a cation-transporting ATPase responsible for maintaining low intracellular Na(+) levels in the parasite.

规格	价格	库存
2 mg	￥1980	In stock
5 mg	￥3580	In stock
10 mg	￥5580	In stock
25 mg	￥8980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SJ733 (SJ000557733, SJ-557733) is an anti-malarial compound that targets ATP4 (PfATP4), a cation-transporting ATPase responsible for maintaining low intracellular Na(+) levels in the parasite.
SJ733 displays high potency in vitro against all tested strains of P. falciparum with EC50 of 10-60 nM.
SJ733 kills parasites and the high fitness cost associated with resistance-conferring mutations appear to slow and suppress the selection of highly drug-resistant mutants in vivo; high oral bioavailability.

物理化学性质&存储条件

分子量	468.412
分子式	C24H16F4N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,4S)-N-(3-Cyano-4-fluorophenyl)-1-oxo-3-(3-pyridinyl)-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydro-4-isoquinolinecarboxamide

参考文献

1. Jiménez-Díaz MB, et al. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5455-62.

2. Crawford ED, et al. PLoS One. 2017 May 22;12(5):e0178163.

3. Mogollon CM, et al. PLoS One. 2016 Dec 20;11(12):e0168362.

SJ733 ((+)-SJ733, SJ000557733, SJ-557733)

生物&药学活性

物理化学性质&存储条件

参考文献

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SJ733 ((+)-SJ733, SJ000557733, SJ-557733)

生物&药学活性

物理化学性质&存储条件

参考文献

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