SJ46420

Chemical Structure : SJ46420

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货号: PC-24903Not For Human Use, Lab Use Only.

SJ46420 is the a methyl-ester prodrug of SJ46421 and specific JQ1-based KLHDC2 PROTAC protein degrader of BRD3, induces selective BRD3 degradation in PC3 cells with DC50 of 487 nM (Dmax=99%).

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生物&药学活性

SJ46420 is the a methyl-ester prodrug of SJ46421 and specific JQ1-based KLHDC2 PROTAC protein degrader of BRD3, induces selective BRD3 degradation in PC3 cells with DC50 of 487 nM (Dmax=99%).

物理化学性质&存储条件

分子量	851.44
分子式	C43H43ClN8O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (S)-(2-(2-(8-(2-(4-(2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetyl)piperazin-1-yl)ethoxy)naphthalen-2-yl)thiazol-4-yl)acetyl)glycinate

参考文献

1. Scott DC, et al. Nat Commun. 2024 Oct 12;15(1):8829.

SJ46420

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物理化学性质&存储条件

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SJ46420

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