SJ-300 (SJ300)

Chemical Structure : SJ-300

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货号: PC-25671Not For Human Use, Lab Use Only.

SJ-300 is a potent and selective inhibitor of the DKK3-LRP1 interaction, effectively reverses the DKK3 inhibition of Aβ clearance.

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生物&药学活性

SJ-300 is a potent and selective inhibitor of the DKK3-LRP1 interaction, effectively reverses the DKK3 inhibition of Aβ clearance.
SJ-300 effectively binds to mLRPIV with a Kd of 7.9 uM.
SJ-300 markedly impeds the binding of DKK3 to mLRPIV with IC50 of 3.2 uM, does not disrupt the binding of Aβ to LRP1.
SJ-300 (5 mg/kg, orally administered (intragastrically), 0.5% O-carboxymethylcellulose-Na in saline) effectively alleviates cognitive and pathological deficits in 5×FAD mice, promotes peripheral clearance in AD model mice.

物理化学性质&存储条件

分子量	342.46
分子式	C20H27FN4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-cyclopropyl-N-((1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)piperidin-4-amine

参考文献

1. Yang R, et al. Sci Adv. 2025 Nov 7;11(45):eadz2099.

SJ-300 (SJ300)

生物&药学活性

物理化学性质&存储条件

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SJ-300 (SJ300)

生物&药学活性

物理化学性质&存储条件

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