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首页-小分子抑制剂&激动剂-Epigenetics-Sirtuin -SIRT2 inhibitor RW-78
SIRT2 inhibitor RW-78

Chemical Structure : SIRT2 inhibitor RW-78

CAS No.:

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SIRT2 inhibitor RW-78 (SIRT2 inhibitor 29)

货号: PC-25496Not For Human Use, Lab Use Only.

SIRT2 inhibitor RW-78 is a potent, ubtype selective, NAD+ independent SIRT2 inhibitor with IC50 of 26 nM, has high selective against SIRT1, 3 and 5, shows cellular target engagement via NanoBRET assays in HEK293T cells with EC50 of 15 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SIRT2 inhibitor RW-78 is a potent, ubtype selective, NAD+ independent SIRT2 inhibitor with IC50 of 26 nM, has high selective against SIRT1, 3 and 5, shows cellular target engagement via NanoBRET assays in HEK293T cells with EC50 of 15 nM.

物理化学性质&存储条件

分子量 537.04
分子式 C26H25ClN6O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-Chloro-4-((3-(2-((4,6-dimethylpyrimidin-2-yl)thio)acetamido)benzyl)oxy)phenyl)-1-methyl-1H-pyrazole-4-carboxamide

参考文献

1. Wirawan R, et al. RSC Med Chem. 2025 Aug 19. doi: 10.1039/d5md00144g.

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