SIRT2 inhibitor 24a

Chemical Structure : SIRT2 inhibitor 24a

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货号: PC-25497Not For Human Use, Lab Use Only.

SIRT2 inhibitor 24a is a potent, subtype selective SIRT2 inhibitor with IC50 of 0.85 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SIRT2 inhibitor 24a is a potent, subtype selective SIRT2 inhibitor with IC50 of 0.85 uM.
SIRT2 inhibitor 24a dose-dependently elevates the acetylation level of α-tubulin in the non-small cell lung cancer H441 cells.
SIRT2 inhibitor 24a restrains cell growth mainly through inhibiting cellular proliferation rather than inducing apoptosis.
SIRT2 inhibitor 24a could suppress the migration and invasion of H441 cells.

物理化学性质&存储条件

分子量	502.59
分子式	C26H26N6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrazole-4-carboxamide, N-[4-[[3-[[2-[(4,6-dimethyl-2-pyrimidinyl)thio]acetyl]amino]phenyl]methoxy]phenyl]-1-methyl-

参考文献

1. Yang LL, et, al. Eur J Med Chem. 2018 Jul 15;155:806-823.

2. Wirawan R, et al. RSC Med Chem. 2025 Aug 19. doi: 10.1039/d5md00144g.