SIR1-365

Chemical Structure : SIR1-365

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货号: PC-24511Not For Human Use, Lab Use Only.

SIR1-365 is a highly potent, selective, and metabolically stable allosteric kinase inhibitor of RIPK1.

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生物&药学活性

SIR1-365 is a highly potent, selective, and metabolically stable allosteric kinase inhibitor of RIPK1.
SIR1-365 efficiently reduces TNF-α-induced mortality and multiorgan damage in systemic inflammatory response syndrome mice disease model.
SIR1-365 significantly increased arterial oxygenation from baseline in hospitalized patients with severe COVID-19.

物理化学性质&存储条件

分子量	257.28
分子式	C13H17F2NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3,5-difluorobenzyl)-N-hydroxy-2,2-dimethylbutanamide

参考文献

1. Chavez-Tapia N, et al. J Intensive Med. 2024 Sep 12;5(1):70-78.

2. Alba GA, et al. EClinicalMedicine. 2021 Aug 28;39:101066.

3. Yan Ren, et al. J Med Chem. 2017 Feb 9;60(3):972-986.

4. Patent WO 2020103859.

SIR1-365

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物理化学性质&存储条件

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SIR1-365

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物理化学性质&存储条件

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