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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-SHP844
SHP844

Chemical Structure : SHP844

CAS No.: 2222280-82-0

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SHP844 (SHP 844)

货号: PC-62629Not For Human Use, Lab Use Only.

SHP844 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 18.9 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SHP844 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 18.9 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).
    SHP844 downregulates DUSP6 mRNA, a downstream MAPK pathway marker, in KYSE-520 cancer cells.
    SHP844 enhances pharmacological pathway inhibition in cells combined with SHP099.

    物理化学性质&存储条件

    分子量 573.99
    分子式 C29H24ClN5O6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3-chloro-4-((1-(2-hydroxy-3-methoxyphenyl)-5-oxo-[1,2,4]triazolo[4,3-a]quinazolin-4(5H)-yl)methyl)benzoyl)-L-proline

    参考文献

    1. Fodor M, et al. ACS Chem Biol. 2018 Jan 18. doi: 10.1021/acschembio.7b00980.

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