SHP1 inhibitor M029

Chemical Structure : SHP1 inhibitor M029

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货号: PC-26204Not For Human Use, Lab Use Only.

SHP1 inhibitor M029 is a covalent, allosteric SHP1 inhibitor with IC50 of 2.6 uM, covalently targets cryptic Cys480 far away from the active site.

规格	价格	库存	数量
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250 mg		Get quote

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生物&药学活性

SHP1 inhibitor M029 is a covalent, allosteric SHP1 inhibitor with IC50 of 2.6 uM, covalently targets cryptic Cys480 far away from the active site.
M029 displays >22.4‐fold selectivity over a large panel of mammalian PTPs, including its closely related homolog SHP2.
M029 shows strong efficacy in immune activation, enhanced TCR‐LCK signaling and T cell activation.
M029 inhibits syngeneic MC38 tumor growth by promoting infiltration and activation of both T cells and NK cells in the tumor microenvironment.

物理化学性质&存储条件

分子量	355.81
分子式	C13H10ClN3O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-(4-(N-(3-cyanothiophen-2-yl)sulfamoyl)phenyl)acetamide

参考文献

1. Zihan Qu, et al. Angew Chem Int Ed Engl. 2026 Feb 9;65(7):e25126.