SHP1 agonist SCA9

Chemical Structure : SHP1 agonist SCA9

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货号: PC-26115Not For Human Use, Lab Use Only.

SHP1 agonist SCA9 is a highly selective covalent agonist of SHP1 (SHP-1) targeting Cys102, binds the N-SH2 domain to relieve autoinhibition and activate SHP1 with EC50 of 13.4 uM.

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生物&药学活性

SHP1 agonist SCA9 is a highly selective covalent agonist of SHP1 (SHP-1) targeting Cys102, binds the N-SH2 domain to relieve autoinhibition and activate SHP1 with EC50 of 13.4 uM.

物理化学性质&存储条件

分子量	314.73
分子式	C14H11ClN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-((5-chloropyrazolo[1,5-a]pyrimidin-7-yl)amino)pyridin-4-yl)acrylamide

参考文献

1. Mei Ying Ng, et al. bioRxiv [Preprint]. 2026 Feb 22:2026.02.19.706790.