SHP1 agonist SCA1

Chemical Structure : SHP1 agonist SCA1

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货号: PC-26114Not For Human Use, Lab Use Only.

SHP1 agonist SCA1 is a highly selective covalent agonist of SHP1 (SHP-1) targeting Cys102, binds the N-SH2 domain to relieve autoinhibition and activate SHP1 with EC50 of 36.4 uM.

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生物&药学活性

SHP1 agonist SCA1 is a highly selective covalent agonist of SHP1 (SHP-1) targeting Cys102, binds the N-SH2 domain to relieve autoinhibition and activate SHP1 with EC50 of 36.4 uM.
SCA1 exhibits a very high degree of proteome-wide selectivity for SHP1 Cys102 at low micromolar concentrations.
SCA1 (5-40 uM) reproducibly and selectively labelled SHP1 Cys102 in THP-1 MDMs.
SCA1 could destabilize the auto-inhibited state of SHP1 and enhance SHP1 phosphatase activity.
SCA1 inhibits TLR4-driven cytokine production, inhibits LPS-induced phosphorylation at STAT3 Tyr705 and Ser727.
SCA1 inhibits production of NF-κB dependent pro-inflammatory cytokines including IL6 and TNF following LPS stimulation in a concentration-dependent manner.
SCA1 antagonizes IRAK signaling and LPS-induced pro-inflammatory cytokine production.

物理化学性质&存储条件

分子量	313.75
分子式	C15H12ClN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((5-chloropyrazolo[1,5-a]pyrimidin-7-yl)amino)phenyl)acrylamide

参考文献

1. Mei Ying Ng, et al. bioRxiv [Preprint]. 2026 Feb 22:2026.02.19.706790.