SGN-2FF | Fucosylation inhibitor | Probechem Biochemicals

Chemical Structure : SGN-2FF

CAS No.: 2089647-47-0

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SGN-2FF (SGN2FF)

货号: PC-73175Not For Human Use, Lab Use Only.

SGN-2FF is a potent and orally active inhibitor of glycoprotein fucosylation, directly inhibits fucosyltransferase activity.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3580	In stock
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100 mg		Get quote

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生物&药学活性

SGN-2FF is a potent and orally active inhibitor of glycoprotein fucosylation, directly inhibits fucosyltransferase activity.
SGN-2FF inhibits cellular fucosylation by depletion of the fucosylation substrate GDP-fucose, as well as by direct inhibition of fucosyltransferases, leading to the production of afucosylated glycoproteins including antibodies.
SGN-2FF has antitumor activity in multiple mouse tumor models, showing substantial tumor growth delay.
SGN-2FF activates human T cells in an antigen-dependent manner, also enhanced the protective effect of a lymphoma vaccine in a syngeneic mouse model.

物理化学性质&存储条件

分子量	166.15
分子式	C6H11FO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	DMSO: 50 mg/mL H2O: 30 mg/mL
Chemical Name/SMILES	rel-(3S,4R,5S,6S)-3-Fluoro-6-methyltetrahydro-2H-pyran-2,4,5-triol

参考文献

1. Khanh T Do, et al. Oncologist. 2021 Nov;26(11):925-e1918.

2. Stephen C. Alley, et al. Cancer Res (2017) 77 (13_Supplement): DDT02-02.

SGN-2FF (SGN2FF)

生物&药学活性

物理化学性质&存储条件

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SGN-2FF (SGN2FF)

生物&药学活性

物理化学性质&存储条件

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