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首页-小分子抑制剂&激动剂-Epigenetics-DNA Methyltransferase (DNMT)-SGI-1027
SGI-1027

Chemical Structure : SGI-1027

CAS No.: 1020149-73-8

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SGI-1027 (SGI1027, SGI 1027)

货号: PC-43810Not For Human Use, Lab Use Only.

SGI-1027 (SGI1027) is a potent inhibitor of DNA methyltransferase (DNMT) with IC50s of 6-12.5 uM for DNMT1, DNMT3A, and DNMT3B.

规格 价格 库存 数量
5 mg ￥580 In stock
10 mg ￥880 In stock
50 mg ￥2180 In stock
100 mg ￥3580 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SGI-1027 (SGI1027) is a potent inhibitor of DNA methyltransferase (DNMT) with IC50s of 6-12.5 uM for DNMT1, DNMT3A, and DNMT3B.
SGI-1027 induces selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B in different cancer cell lines.

物理化学性质&存储条件

分子量 461.5178
分子式 C27H23N7O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 27 mg/mL
Chemical Name/SMILES

Benzamide, N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)-

参考文献

1. Datta J, et al. Cancer Res. 2009 May 15;69(10):4277-85.

2. Rilova E, et al. ChemMedChem. 2014 Mar;9(3):590-601.

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