SGC-CK1γ-1

Chemical Structure : SGC-CK1γ-1

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货号: PC-25588Not For Human Use, Lab Use Only.

规格	价格	库存	数量
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生物&药学活性

SGC-CK1γ-1 is the first chemical probe inhibitor of casein kinase 1γ (CK1γ) subfamily (CK1γ1, CK1γ2, and CK1γ3) with IC50 of 180,180 and 230 nM in NanoBRET assays respectively, inhibits both WNT signaling and human cytomegalovirus replication.
SGC-CK1γ-1 demonstrates a cellular IC50 of <1 μM, a biochemical IC50 <100 nM, good aqueous solubility in DLS, and excellent kinome-wide selectivity.
SGC-CK1γ-1 potently inhibits CK1γ1 / CK1γ2 / CK1γ3 with IC50 of 28/ 7/ 958 nM in enzymatic assays.
SGC-CK1γ-1 (5 uM) induces significant loss of LRP6 phosphorylation at T1479 in HEK293 cells, does not impact cell viability.
SGC-CK1γ-1 elicited anti-HCMV replication effects with no noticeable impact on cell viability when used at 10 µM.

物理化学性质&存储条件

分子量	353.81
分子式	C18H16ClN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3-chloro-4-morpholinophenyl)amino)-1H-benzo[d]imidazole-6-carbonitrile

参考文献

1. Capener JL, et al. bioRxiv [Preprint]. 2025 Sep 16:2025.09.10.675406.

SGC-CK1γ-1

生物&药学活性

物理化学性质&存储条件

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SGC-CK1γ-1

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