SEW84 (SEW04784) | AHA1 inhibitor | Probechem Biochemicals

Chemical Structure : SEW84

CAS No.: 259089-67-3

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SEW84 (SEW04784, SEW 04784, SEW 84)

货号: PC-38267Not For Human Use, Lab Use Only.

SEW84 (SEW04784) is a first-in-class, specific inhibitor of the Aha1-stimulated Hsp90 (ASH) ATPase activity (IC50=0.3 uM) without inhibiting basal Hsp90 ATPase.

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10 mg	￥880	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

SEW84 (SEW04784) is a first-in-class, specific inhibitor of the Aha1-stimulated Hsp90 (ASH) ATPase activity (IC50=0.3 uM) without inhibiting basal Hsp90 ATPase.
SEW84 binds to the C-terminal domain of Aha1 (Kd=1.7 uM) to weaken its asymmetric binding to Hsp90.
SEW84 inhibited the GR- and AR-dependent luciferase expression with IC50 of 1.3 uM and 0.7 uM respectively.
SEW84 blocks Aha1-dependent Hsp90 chaperoning activities, including the in vitro and in vivo refolding of firefly luciferase, and the transcriptional activity of the androgen receptor in cell-based models of prostate cancer.
SEW84 promotes the clearance of phosphorylated tau in cellular and tissue models of neurodegenerative tauopathy.

物理化学性质&存储条件

分子量	422.402
分子式	C19H14F4N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1-(4-fluorophenyl)-1H-pyrrole-2-carbonyl)-N-(3-(trifluoromethyl)phenyl)hydrazine-1-carbothioamide

参考文献

1. Jay K Singh, et al. Cell Chem Biol. 2020 Mar 19;27(3):292-305.e6.

SEW84 (SEW04784, SEW 04784, SEW 84)

生物&药学活性

物理化学性质&存储条件

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SEW84 (SEW04784, SEW 04784, SEW 84)

生物&药学活性

物理化学性质&存储条件

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