SERCA2a activator A | SERCA2a activator | Probechem Biochemicals

Chemical Structure : SERCA2a activator A

CAS No.: 2139330-34-8

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SERCA2a activator A (Compound A)

货号: PC-61779Not For Human Use, Lab Use Only.

SERCA2a activator A is a novel sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a (SERCA2a) activator that activates the Ca2+-dependent ATPase activity of cardiac SR vesicles but not that of skeletal muscle SR vesicles that lack of phospholamban (PLN).

规格	价格	库存
1 mg	￥1780	In stock
5 mg	￥3980	In stock
10 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SERCA2a activator A is a novel sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a (SERCA2a) activator that activates the Ca2+-dependent ATPase activity of cardiac SR vesicles but not that of skeletal muscle SR vesicles that lack of phospholamban (PLN).
SERCA2a activator A binds to PLN (Kd=75 uM), attenuates its inhibition of SERCA2a; enhances systolic and diastolic functions in rat hearts.

物理化学性质&存储条件

分子量	551.661
分子式	C32H29N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5'-benzyl-1'-butyl-N-(naphthalen-2-ylsulfonyl)-6'-oxo-1',6'-dihydro-[2,3'-bipyridine]-4-carboxamide

参考文献

1. Kaneko M, et al. Eur J Pharmacol. 2017 Nov 5;814:1-8.

SERCA2a activator A (Compound A)

生物&药学活性

物理化学性质&存储条件

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SERCA2a activator A (Compound A)

生物&药学活性

物理化学性质&存储条件

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