SDL01

Chemical Structure : SDL01

加入收藏

货号: PC-23509Not For Human Use, Lab Use Only.

SDL01 is a specific small molecule allosteric modulator / enhancer of the interaction between AIMP2-DX2 (DX2) and Siah1, promotes DX2 degradation by Siah1 with IC50 of 1.09 uM in A549 cells.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SDL01 is a specific small molecule allosteric modulator / enhancer of the interaction between AIMP2-DX2 (DX2) and Siah1, promotes DX2 degradation by Siah1 with IC50 of 1.09 uM in A549 cells.
SDL01 binds to the pocket surrounding the N-terminal flexible region and GST domain of DX2, causing a conformational change that stabilized its interaction with Siah1.
SDL01 enhanced the direct binding of Siah1, but not that of HSP70, to DX2.
SDL01-induced degradation of DX2 affected cell viability with EC50 of 0.94 uM in A549 cells.
SDL01 effectively reduced the size of the spheroids and induced cytotoxicity in a dose-dependent manner in H460 cells.
SDL01 (40 mg/kg, i.p.) decreased tumor size and weight in xenograft assays using H460 cells, with no significant effect on body weight
SDL01 induced ubiquitination of DX2 at lysine 90, increased Siah1-dependent ubiquitination of the WT DX2 and K7A mutant but not in the K90A mutant。
AIMP2-DX2 (DX2) is an oncogenic variant of aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) that mediates tumorigenic interactions with various factors involved in cancer.

物理化学性质&存储条件

分子量	473.61
分子式	C23H27N3O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-4-methyl-2-((4-methylphenyl)sulfonamido)pentanamide

参考文献

1. Kim DG, et al. Cell Chem Biol. 2024 Nov 21;31(11):1958-1968.e8.

SDL01

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SDL01

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.