SD-91

Chemical Structure : SD-91

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货号: PC-24975Not For Human Use, Lab Use Only.

SD-91 is a potent, selective STAT3 PROTAC degrader with DC50 of 17 nM in SU-DHL-1 cell line.

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生物&药学活性

SD-91 is a potent, selective STAT3 PROTAC degrader with DC50 of 17 nM in SU-DHL-1 cell line.
SD-91 binds to STAT3 protein with a high affinity and displays >300-fold selectivity over other STAT family protein members.
SD-91 potently and effectively induces degradation of STAT3 protein and displays a high selectivity over other STAT members and >7000 non-STAT proteins in cells.
SD-91 selectively depletes STAT3 protein in tumor tissues with a persistent effect. complete and long-lasting tumor regression in the MOLM-16 xenograft model in mice.

物理化学性质&存储条件

分子量
分子式	C59H62N9O13P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-(8-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oct-7-ynoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indole-5-carbonyl)phosphonic acid

参考文献

1. Zhou H, et al. ACS Med Chem Lett. 2021 May 10;12(6):996-1004.

SD-91

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物理化学性质&存储条件

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SD-91

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物理化学性质&存储条件

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