SCR130

Chemical Structure : SCR130

CAS No.: 2377858-38-1

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货号: PC-24672Not For Human Use, Lab Use Only.

SCR130 is a small-molecule inhibitor of nonhomologous end-joining (NHEJ), specifically inhibits Ligase IV with minimal or no effect on Ligase III and Ligase I mediated joining.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1480	In stock
100 mg		Get quote

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生物&药学活性

SCR130 is a small-molecule inhibitor of nonhomologous end-joining (NHEJ), specifically inhibits Ligase IV with minimal or no effect on Ligase III and Ligase I mediated joining.
SCR130 led to loss of mitochondrial membrane potential leading to cell death by activating both intrinsic and extrinsic pathways of apoptosis.
SCR130 can potentiate the effect of radiation in cancer cells when used in combination with γ-radiation.

物理化学性质&存储条件

分子量	418.29
分子式	C19H13Cl2N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-

参考文献

1. Ujjayinee Ray, et al. Mol Carcinog. 2020 Jun;59(6):618-628.

2. Hildebrand LS, et al. Sci Rep. 2025 May 22;15(1):17871.

SCR130

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SCR130

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