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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Nitric Oxide Synthase (NOS)-SCR-4026
SCR-4026

Chemical Structure : SCR-4026

CAS No.: 2185855-51-8

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SCR-4026 (SCR4026)

货号: PC-25145Not For Human Use, Lab Use Only.

SCR-4026 is a small molecule inhibitor of nNOS-PSD95 interaction, disrupts nNOS-PSD-95 association with an IC50 of 6.3 μM in vitro.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SCR-4026 is a small molecule inhibitor of nNOS-PSD95 interaction, disrupts nNOS-PSD-95 association with an IC50 of 6.3 μM in vitro.
SCR-4026 blocks NMDA-induced cell injury efficiently in cultured cortical neurons.
SCR-4026 prevents cytotoxicity induced by OGD. SCR-4026 blocks nNOS-PSD-95 interaction in cultured neurons in an NMDA model.
SCR-4026 (5 mg/kg, i.v.) significantly reduced the neurological deficit scores in MCAO model.

物理化学性质&存储条件

分子量 311.16
分子式 C14H12Cl2N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((2-amino-4,6-dichlorophenoxy)methyl)benzamide

参考文献

1. Mo SF, et al. Brain Res. 2016 Oct 1;1648(Pt A):250-256.

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