SCP1 inhibitor GR-28 | SCP1/REST inhibitor | Probechem Biochemicals

Chemical Structure : SCP1 inhibitor GR-28

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SCP1 inhibitor GR-28 (GR-28)

货号: PC-22168Not For Human Use, Lab Use Only.

SCP1 inhibitor GR-28 is a covalent small molecule inhibitor of small C-terminal domain phosphatase 1 (SCP1) with kinact/KI 1383 min-1 M-1, causes degrades REST protein in REST-dependent glioblastoma cells.

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生物&药学活性

SCP1 inhibitor GR-28 is a covalent small molecule inhibitor of small C-terminal domain phosphatase 1 (SCP1) with kinact/KI 1383 min-1 M-1, causes degrades REST protein in REST-dependent glioblastoma cells.
GR-28 inhibits SCP1 capacity to dephosphorylate REST leading to accumulation of phospho-REST and its subsequent proteasomal degradation in vitro.
SCP1 inhibitor GR-28 covalently targets SCP1 Cys 181, and SCP1 C181A mutant shows resistance to GR-28 inhibition.
SCP1 inhibitor GR-28 (4 uM) reduces the transcriptional activity of REST and GR-28 (10 uM) is cytotoxic against high-REST GBM cells.
SCP1 inhibitor GR-28 exhibits profound synergy with ACSL inhibitor Triacsin C in high-REST GBM cells.

物理化学性质&存储条件

分子量	476.55
分子式	C26H24N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(2'-methoxy-[1,1'-biphenyl]-4-carboxamido)propyl)cinnamamide 1,1-dioxide

参考文献

1. Svetlana B Panina, et al. BMC Biol. 2024 Apr 12;22(1):83.

SCP1 inhibitor GR-28 (GR-28)

生物&药学活性

物理化学性质&存储条件

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SCP1 inhibitor GR-28 (GR-28)

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物理化学性质&存储条件

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