SC75741 | NF-κB inhibitor, c-Abl inhibitor | Probechem Biochemicals

Chemical Structure : SC75741

CAS No.: 913822-46-5

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SC75741 (SC-75741)

货号: PC-28152Not For Human Use, Lab Use Only.

SC75741 is a specific small molecule NF-κB inhibitor, inhibits DNA binding of NF-κB subunit p65 with IC50 of 200 nM, efficiently blocks influenza virus propagation, also promotes the elimination of TDP25 and TDP43-related aggregates by inhibiting c-Abl (IC50=263 nM).

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

SC75741 is a specific small molecule NF-κB inhibitor, inhibits DNA binding of NF-κB subunit p65 with IC50 of 200 nM, efficiently blocks influenza virus propagation, also promotes the elimination of TDP25 and TDP43-related aggregates by inhibiting c-Abl (IC50=263 nM).
SC75741 reduces expression of cytokines, chemokines, and pro-apoptotic factors, subsequent inhibition of caspase activation and block of caspase-mediated nuclear export of viral ribonucleoproteins.
SC75741 reduces viral replication and H5N1-induced IL-6 and IP-10 expression in the lung of infected mice.
SC75741 suppresses H5N1 virus-induced overproduction of cytokines and chemokines.
SC75741 significantly protects mice against infection with highly pathogenic avian influenza A viruses of the H5N1 and H7N7 subtypes.
SC75741 reduces viral RNA synthesis of Severe fever with thrombocytopenia syndrome virus (SFTSV) and Heartland virus (HRTV).
SC75741 promotes the degradation of TDP-43-related protein aggregation and reduces the inflammation-induced aggregation by inhibiting NF-κB pathway.
SC75741 degrades already aggregated proteins by inhibiting c-Abl mediated autophagy-lysosomal pathway.

物理化学性质&存储条件

分子量	565.67
分子式	C29H23N7O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-Benzoyl-1H-benzo[d]imidazol-2-yl)-2-(1-(thieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)thiazole-4-carboxamide

参考文献

1. Ehrhardt C, et al. Cell Microbiol. 2013 Jul;15(7):1198-211.

2. Haasbach E, et al. Antiviral Res. 2013 Sep;99(3):336-44.

3. Mendoza CA, et al. Antiviral Res. 2021 Jan;185:104993.

4. Zhou D, et al. Front Pharmacol. 2021 Oct 29;12:741219.

SC75741 (SC-75741)

生物&药学活性

物理化学性质&存储条件

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SC75741 (SC-75741)

生物&药学活性

物理化学性质&存储条件

参考文献

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