SC-919 (LI-2124) | IP6K inhibitor | Probechem Biochemicals

Chemical Structure : SC-919

CAS No.: 2245949-62-4

加入收藏

SC-919 (SC919, LI-2124)

货号: PC-72584Not For Human Use, Lab Use Only.

SC-919 (SC919) is a potent, selective inhibitor of IP6K (Inositol hexakisphosphate kinase) with IC50 of <5.2, <3.8 and 0.65 nM for human IP6K1/2/3, respectively.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5280	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SC-919 (SC919) is a potent, selective inhibitor of IP6K (Inositol hexakisphosphate kinase) with IC50 of <5.2, <3.8 and 0.65 nM for human IP6K1/2/3, respectively.
SC-919 reduces the export of phosphate in 293 cells via an XPR1-dependent mechanism involving the SPX domain, reduces intracellular InsP7 levels.
SC-919 decreases plasma phosphate levels in rats and monkeys and does not inhibit phosphate intake by the gut or phosphate reuptake by the kidney in rats.
SC-919 decreases the plasma phosphate levels in rats with hyperphosphataemia.
SC-919 increases the intracellular levels of ATP in an XPR1-dependent manner.
SC-919 alleviates CKD-induced hyperphosphataemia and related parameters in adenine-treated rats.

物理化学性质&存储条件

分子量	407.247
分子式	C19H16Cl2N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1s,4s)-4-((3,5-dichloropyridin-2-yl)oxy)-2'-oxospiro[cyclohexane-1,3'-indoline]-5'-carboxylic acid

参考文献

1. Yusuke Moritoh, et al. Nat Commun. 2021 Aug 11;12(1):4847.

SC-919 (SC919, LI-2124)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SC-919 (SC919, LI-2124)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.