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首页-小分子抑制剂&激动剂-Autophagy-ULK-SBP-1750
SBP-1750

Chemical Structure : SBP-1750

CAS No.: 1884219-70-8

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SBP-1750 (SBP1750)

货号: PC-25796Not For Human Use, Lab Use Only.

SBP-1750 is a novel potent ULK inhibitor with IC50 of 8 nM and 50 nM for ULK1 and ULK2 respectively in ADP-Glo kinase assays, induces effective ATG13 degradation in A549 cells with EC50 of 114 nM in In-Cell Western blots (ICWBs) assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SBP-1750 is a novel potent ULK inhibitor with IC50 of 8 nM and 50 nM for ULK1 and ULK2 respectively in ADP-Glo kinase assays, induces effective ATG13 degradation in A549 cells with EC50 of 114 nM in In-Cell Western blots (ICWBs) assays.
SBP-1750 exhibits cellular activity in the ULK1 NanoBRET assay with IC50 of 4.1 nM.
SBP-1750 may induce ATG13 degradation through a proteasomal pathway, MG132 significantly alters the level of ATG13 degradation.
SBP-1750 impaired ATG, and induced KRAS mutant cancer cell death.
SBP-1750 significantly reduced tumor growth in KRAS-mutant orthotopic syngeneic pancreatic cancer model.

物理化学性质&存储条件

分子量 443.89
分子式 C21H22ClN5O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((5-chloro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

参考文献

1. Hagan PM, et al. bioRxiv [Preprint]. 2025 Oct 15:2025.10.14.682402.

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