SBI-810 | NTSR1 modulator | Probechem Biochemicals

Chemical Structure : SBI-810

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SBI-810 (SBI 810)

货号: PC-24645Not For Human Use, Lab Use Only.

SBI-810 is a potent, selective arrestin-biased allosteric modulator of neurotensin receptor 1 (NTSR1, NTR1).

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生物&药学活性

SBI-810 is a potent, selective arrestin-biased allosteric modulator of neurotensin receptor 1 (NTSR1, NTR1).
SBI-810 inhibits acute pain in naive mice through NTSR1 and βarr2.
SBI-810 stimulated βarr2 recruitment to the human NTSR1, failed to stimulate NTSR1-mediated activation of Gq.
SBI-810 (12 mg/kg, i.p.) effectively alleviated mechanical, spontaneous, and cold pain in mouse model of plantar incision-induced postoperative pain.
SBI-810 blocks peripheral and central sensitization in DRG and spinal cord neurons.
SBI-810 mitigates opioid abuse and does not impair motor and cognitive function

物理化学性质&存储条件

分子量	446.60
分子式	C27H34N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((4-(4-(2-methoxyphenyl)piperidin-1-yl)-2-(1-methylcyclopropyl)quinazolin-6-yl)(methyl)amino)ethan-1-ol

参考文献

1. Guo R, et al. Cell. 2025 May 15:S0092-8674(25)00508-2.

SBI-810 (SBI 810)

生物&药学活性

物理化学性质&存储条件

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SBI-810 (SBI 810)

生物&药学活性

物理化学性质&存储条件

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