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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-SBHA
SBHA

Chemical Structure : SBHA

CAS No.: 38937-66-5

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SBHA (Suberoyl bis-hydroxamic acid, Suberohydroxamic acid)

货号: PC-28355Not For Human Use, Lab Use Only.

SBHA (Suberoyl bis-hydroxamic acid) is a competitive and cell-permeable HDAC1 and HDAC3 inhibitor with ID50 values of 0.25 μM and 0.30 μM, respectively, renders MM cells susceptible to apoptosis and facilitates the mitochondrial apoptotic pathways.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SBHA (Suberoyl bis-hydroxamic acid) is a competitive and cell-permeable HDAC1 and HDAC3 inhibitor with ID50 values of 0.25 μM and 0.30 μM, respectively, renders MM cells susceptible to apoptosis and facilitates the mitochondrial apoptotic pathways, induces accumulation of hyperacetylated histone H4 in cultured cells.

物理化学性质&存储条件

分子量 204.23
分子式 C8H16N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N1,N8-Dihydroxyoctanediamide

参考文献

1. Brinkmann H, et al. J Biol Chem. 2001 Jun 22;276(25):22491-9.

2. Jiri Neuzil, et al. Biochem Biophys Res Commun. 2004 Jan 30;314(1):186-91.

3. V M Richon, et al. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3003-7.

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