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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Checkpoint Kinase (Chk)-SB218078
SB218078

Chemical Structure : SB218078

CAS No.: 135897-06-2

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SB218078 (SB-218078, SB 218078)

货号: PC-60290Not For Human Use, Lab Use Only.

SB218078 (SB-218078) is a potent inhibitor of Chk1 that blocks phosphorylation of cdc25 with IC50 of 15 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SB218078 (SB-218078) is a potent inhibitor of Chk1 that blocks phosphorylation of cdc25 with IC50 of 15 nM.
SB218078 less potently inhibits Cdc2 and PKC (IC50=250 and 1,000 nM, respectively) and causes 85% inhibition of PKD1 at 1 uM.
SB218078 enhances the cytotoxicity of DNA-damaging agents.

物理化学性质&存储条件

分子量 393.4
分子式 C24H15N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5,6,7,8-tetrahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-13,15(14H)-dione

参考文献

1. Jackson JR, et al. Cancer Res. 2000 Feb 1;60(3):566-72.

2. Fishler T, et al. Oncogene. 2010 Jul 15;29(28):4007-17.

3. Akasaka T, et al. Int J Oncol. 2015 Jan;46(1):63-70.

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