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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-p38 MAPK-SB 202190
SB 202190

Chemical Structure : SB 202190

CAS No.: 152121-30-7

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SB 202190 (SB202190, SB-202190)

货号: PC-42512Not For Human Use, Lab Use Only.

SB 202190 (SB202190, SB-202190) is a potent inhibitor p38α and p38β with IC50 of 50 nM and 100 nM respectively.

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25 mg ￥980 In stock
50 mg ￥1480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SB 202190 (SB202190, SB-202190) is a potent inhibitor p38α and p38β with IC50 of 50 nM and 100 nM respectively.
SB 202190 stimulates the activity of CPP32-like caspases, potentiates apoptosis induced by Fas(APO-1) ligation or UV irradiation.

物理化学性质&存储条件

分子量 331.343
分子式 C20H14FN3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 40 mg/mL
Chemical Name/SMILES

Phenol, 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-

参考文献

1. Davies SP, et al. Biochem J. 2000 Oct 1;351(Pt 1):95-105.

2. Nemoto S, et al. J Biol Chem. 1998 Jun 26;273(26):16415-20.

3. Manthey CL, et al. J Leukoc Biol. 1998 Sep;64(3):409-17.

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