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首页-小分子抑制剂&激动剂-GPCR-Urotensin Receptor-SB-710411
SB-710411

Chemical Structure : SB-710411

CAS No.: 209006-05-3

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SB-710411 (SB710411)

货号: PC-28270Not For Human Use, Lab Use Only.

SB-710411 is a selective peptidic urotensin-II receptor (UTR, U-II receptor, GPR14) antagonist, inhibits [(125)I]urotensin-II rat and monkey UT receptor binding with pKi of 7.50 and 6.85 respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SB-710411 is a selective peptidic urotensin-II receptor (UTR, U-II receptor, GPR14) antagonist, inhibits [(125)I]urotensin-II rat and monkey UT receptor binding with pKi of 7.50 and 6.85 respectively.
SB-710411 inhibits hU-II-induced contraction in rat isolated aorta causing a significant, parallel shift in the agonist concentration-response curve (pK(b) 6.28.
SB-710411 antagonizes urotensin-II-induced inositol phosphate formation at the rat UT receptor (pK(b) 6.54).
SB-710411 functions as an agonist at the monkey UT receptor (pEC(50) 6.56).

物理化学性质&存储条件

分子量 1146.22
分子式 C54H66Cl2N12O8S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Cpa-c[D-Cys-Pal-D-Trp-Lys-Val-Cys]-Cpa-amide

参考文献

1. Behm DJ, et al. Br J Pharmacol. 2002 Oct;137(4):449-58.

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