SARS-CoV-2 Mpro inhibitor H102

Chemical Structure : SARS-CoV-2 Mpro inhibitor H102

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货号: PC-25564Not For Human Use, Lab Use Only.

SARS-CoV-2 Mpro inhibitor H102 is a potent covalent inhibitor of SARS-CoV-2 Mpro with IC50 of 8.8 nM.

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250 mg		Get quote

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生物&药学活性

SARS-CoV-2 Mpro inhibitor H102 is a potent covalent inhibitor of SARS-CoV-2 Mpro with IC50 of 8.8 nM.
H102 is more potent than another reported aldehyde Mpro inhibitor GC376 (IC50 of 24.5 nM) and Nirmatrelvir (PF-07321332, IC50 of 22.2 nM).
H102 effectively decreases viral replication by 3.55 log10 at 10 µM and 1.34 log10 at 2.5 µM, respectively, in VeroE6 cells by viral load reduction assay.
H102 inhibits viral replication with an EC50 of 168.9 nM in VeroE6 cells without cytotoxicity at >50 uM.

物理化学性质&存储条件

分子量	498.62
分子式	C24H42N4O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(6S,9S,12S)-6-(tert-butyl)-9-isobutyl-2,2-dimethyl-4,7,10-trioxo-12-(((S)-2-oxopyrrolidin-3-yl)methyl)-3-oxa-5,8,11-triazatridecan-13-oic acid

参考文献

1. Wang J, et al. J Virol. 2025 Sep 15:e0065825.