SARM1 inhibitor NB-7 | SARM1 inhibitor | Probechem Biochemicals

Chemical Structure : SARM1 inhibitor NB-7

CAS No.: 2665712-31-0

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SARM1 inhibitor NB-7 (NB7)

货号: PC-24261Not For Human Use, Lab Use Only.

SARM1 inhibitor NB-7 is a potent, selective and uncompetitive inhibitor of the nicotinamide adenine dinucleotide (NAD) hydrolase SARM1 with biochemical IC50 of 0.025 uM, and IC50 of 0.008 uM in SARM-induced cell-death rescue assays.

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5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5280	In stock
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100 mg		Get quote

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生物&药学活性

SARM1 inhibitor NB-7 is a potent, selective and uncompetitive inhibitor of the nicotinamide adenine dinucleotide (NAD) hydrolase SARM1 with biochemical IC50 of 0.025 uM, and IC50 of 0.008 uM in SARM-induced cell-death rescue assays.
NB-7 potently protectes against axon degeneration with IC50 of 0.11 uM in cellular models of nerve injury.

物理化学性质&存储条件

分子量	340.81
分子式	C18H17ClN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-chlorophenyl)-N-(4-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)propanamide

参考文献

1. Matthew Bratkowski, et al. Neuron. 2022 Nov 16;110(22):3711-3726.e16.

SARM1 inhibitor NB-7 (NB7)

生物&药学活性

物理化学性质&存储条件

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SARM1 inhibitor NB-7 (NB7)

生物&药学活性

物理化学性质&存储条件

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