SALAD1

Chemical Structure : SALAD1

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货号: PC-25296Not For Human Use, Lab Use Only.

SALAD1 is a cell-permeable ultrabright RNA-activated fluorophore, facilitates improved in-cell confocal RNA imaging, binds to Mango II in a distinctive manner.

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生物&药学活性

SALAD1 is a cell-permeable ultrabright RNA-activated fluorophore, facilitates improved in-cell confocal RNA imaging, binds to Mango II in a distinctive manner.
SALAD1 exhibitsa 3.5-fold improved brightness relative to TO1–biotin, which is typically used in cellular imaging with Mango aptamers.
SALAD1 (KDapp =0.69 ±0.1 nM) binds 7.5-fold more tightly to Mango II compared to TO (KDapp =5.9 ±1.4 nM).
SALAD1 exhibits a binding preference to its target RNA (Mango II) over the other three Mango aptamers (7-, 20- and 16-fold tighter than Mango I, III and IV.

物理化学性质&存储条件

分子量	522.62
分子式	C30H25FN5OS+
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(2-((2-fluoro-6-(1H-pyrazol-1-yl)benzyl)amino)-2-oxoethyl)-2-((1-methylquinolin-4(1H)-ylidene)methyl)benzo[d]thiazol-3-ium

参考文献

1. Mo Yang, et al. Nat Chem. 2025 Aug;17(8):1188-1195. doi: 10.1038/s41557-025-01832-w.

SALAD1

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物理化学性质&存储条件

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SALAD1

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物理化学性质&存储条件

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