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首页-小分子抑制剂&激动剂-Others-Other Targets-S202
S202

Chemical Structure : S202

CAS No.: 2169248-42-2

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S202 (CGT inhibitor S202)

货号: PC-38767Not For Human Use, Lab Use Only.

S202 is a potent, selective and brain-penetrant small molecule inhibitor of ceramide galactosyltransferase (CGT) with IC50 of 15 nM in the cell-lysate assays and 3.6 nM in intact-cell assays.

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纯度 & COA & 质检文件 纯度: 99.38% (HPLC) Select Batch:

生物&药学活性

S202 is a potent, selective and brain-penetrant small molecule inhibitor of ceramide galactosyltransferase (CGT) with IC50 of 15 nM in the cell-lysate assays and 3.6 nM in intact-cell assays.
S202 exhibits minimal to no activity toward other enzymes that act on related glycosphingolipids.
S202 preferentially reduces non-hydroxy-GalCer synthesis in vivo.
S202 (0-1.5 mg/kg) extends survival and reduces psychosine levels in a krabbe disease (KD) mouse model, causes a dose-dependent reduction in non-hydroxy-GalCer without reducing 2-hydroxy-GalCer in the brain.
S202 (0.15 mg/kg, i.p. three times per week) improves histological and immunological markers in Twitcher mice.
S202 treatment reduces non-hydroxy-sulfatides and lysosulfatide in an MLD mouse model.

物理化学性质&存储条件

分子量 586.203
分子式 C23H17Br2F3N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(5R)-1,3-bis(4-bromophenyl)-4-hydroxy-5-methyl-4-(3-(trifluoromethoxy)phenyl)imidazolidin-2-one

参考文献

1. Michael C Babcock, et al. Sci Rep. 2021 Jul 14;11(1):14486.

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