S-570 (S570)

Chemical Structure : S-570

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货号: PC-27724Not For Human Use, Lab Use Only.

S-570 is a potent, covalent, orally available STING antagonist with IC50 of 41 nM (hSTING), covalently binds to Cys91, inhibits IFN-β secretion in 2′,3′-cGAMP-stimulated THP-1 cells with IC50 of 18 nM.

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生物&药学活性

S-570 is a potent, covalent, orally available STING antagonist with IC50 of 41 nM (hSTING), covalently binds to Cys91, inhibits IFN-β secretion in 2′,3′-cGAMP-stimulated THP-1 cells with IC50 of 18 nM.
S-570 selectively inhibits STING signaling while showing only minimal activity against RIG-I- or TLR4-mediated innate immune signaling pathways.
S-570 also exhibits potent antagonist activity against mouse STING with IC50 of 71 nM in cell-based reporter assay using B16 cells stimulated with the STING agonist CMA (10-carboxymethyl-9-acridanone).
S-570 significantly suppressed plasma levels of IFN-β, IL-6 and TNF-α stimulated by CMA in mice.
S-570 effectively attenuated systemic inflammation in a CMA-stimulated mouse model.

物理化学性质&存储条件

分子量	364.76
分子式	C17H12ClF3N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-chloro-1H-indol-3-yl)-1-methyl-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine

参考文献

1. Kiyoi T, et al. Bioorg Med Chem Lett. 2026 Aug 6;141:130757.

S-570 (S570)

生物&药学活性

物理化学性质&存储条件

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S-570 (S570)

生物&药学活性

物理化学性质&存储条件

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