Rottlerin (Mallotoxin, NSC 94525)

Chemical Structure : Rottlerin

CAS No.: 82-08-6

加入收藏

货号: PC-61793Not For Human Use, Lab Use Only.

Rottlerin (Mallotoxin, NSC 94525) is a polyphenol natural product, cell-permeable and reversible PKC inhibitor that exhibits greater selectivity for PKCδ (IC50=3-6 uM) and PKCθ, with significantly reduced potency (IC50=30-42 uM) for PKCα, PKCβ, and PKCγ.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Rottlerin (Mallotoxin, NSC 94525) is a polyphenol natural product, cell-permeable and reversible PKC inhibitor that exhibits greater selectivity for PKCδ (IC50=3-6 uM) and PKCθ, with significantly reduced potency (IC50=30-42 uM) for PKCα, PKCβ, and PKCγ.
Rottlerin (Mallotoxin, NSC 94525) also inhibits CaMK III, suppresses eEF-2 phosphorylation with IC50 of 5.3 uM.
Rottlerin (Mallotoxin, NSC 94525) also remarkably inhibits MACC1 promoter activity and expression, reduces cell motility in CRC cells.

物理化学性质&存储条件

分子量	516.54
分子式	C30H28O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one

参考文献

1. Villalba M, et al. J Immunol. 1999 Dec 1;163(11):5813-9.

2. Gschwendt M, et al. FEBS Lett. 1994 Jan 24;338(1):85-8.

3. Juneja M, et al. PLoS Biol. 2017 Jun 1;15(6):e2000784.