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首页-小分子抑制剂&激动剂-NF-κB Pathway-NF-κB-Ro106-9920
Ro106-9920

Chemical Structure : Ro106-9920

CAS No.: 62645-28-7

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Ro106-9920 (Ro 106-9920)

货号: PC-24857Not For Human Use, Lab Use Only.

Ro106-9920 is a specific small molecule inhibitor of NF-kappa B-dependent cytokine expression with IC50 of <1 uM in human PBMSc, selectively inhibits IkappaB(alpha)(ee) ubiquitination with with iC50 of 2.3 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Ro106-9920 is a specific small molecule inhibitor of NF-kappa B-dependent cytokine expression with IC50 of <1 uM in human PBMSc, selectively inhibits IkappaB(alpha)(ee) ubiquitination with with iC50 of 2.3 uM.
Ro106-9920 is selective for IkappaB(alpha)(ee) ubiquitination over the ubiquitin-activating enzyme (E1), E2UBCH7, nonspecific ubiquitination of cellular proteins, and 97 other molecular targets.

物理化学性质&存储条件

分子量 245.26
分子式 C10H7N5OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(benzenesulfinyl)tetrazolo[1,5-b]pyridazine

参考文献

1. Swinney DC, et al. J Biol Chem. 2002 Jun 28;277(26):23573-81.

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