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首页-小分子抑制剂&激动剂-Others-Other Targets-Rivasterat
Rivasterat

Chemical Structure : Rivasterat

CAS No.: 2446590-96-9

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Rivasterat (CU06-1004, Sac-1004)

货号: PC-25025Not For Human Use, Lab Use Only.

Rivasterat (CU06-1004, Sac-1004) is a small molecule vascular leakage blocker and endothelial dysfunction blocker, inhibits endothelial hyperpermeability induced by VEGF, histamine and thrombin via stabilization of cortical actin ring and AJ proteins at the cell-cell junction.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Rivasterat (CU06-1004, Sac-1004) is a small molecule vascular leakage blocker and endothelial dysfunction blocker, inhibits endothelial hyperpermeability induced by VEGF, histamine and thrombin via stabilization of cortical actin ring and AJ proteins at the cell-cell junction.
Treatment of Rivasterat (CU06-1004, Sac-1004) in ECs increased cAMP levels and activated Rac, both of which are known to strengthen endothelial barrier.
Rivasterat (CU06-1004, Sac-1004) blocks vascular leakage by enhancing endothelial integrity via the cAMP/Rac/cortactin pathway.
Rivasterat (CU06-1004, Sac-1004) reduces cerebral ischemia-reperfusion injury by suppressing blood-brain barrier disruption and inflammation
Rivasterat (CU06-1004, Sac-1004) inhibited angiogenesis and confirmed vascular stabilization in the oxygen-induced retinopathy model.

物理化学性质&存储条件

分子量 626.83
分子式 C37H54O8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

methyl (E)-6-((3S,8S,9S,10R,13S,14S,17R)-3-(((2S,5S,6R)-5-acetoxy-6-(acetoxymethyl)-5,6-dihydro-2H-pyran-2-yl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)hept-5-enoate

参考文献

1. Zhang H, et al. Exp Mol Med. 2022 Jan;54(1):23-34.

2. Noh M, et al. Eur J Pharmacol. 2023 Jan 15;939:175427.

3. Agrawal V, et al. Oncotarget. 2014 May 15;5(9):2761-77.

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