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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Dickkopf-1 (Dkk-1)-Risedronate
Risedronate

Chemical Structure : Risedronate

CAS No.: 105462-24-6

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Risedronate (Risedronic acid)

货号: PC-26883Not For Human Use, Lab Use Only.

Risedronate (Risedronic acid) is a bisphosphonate and potent antiresorptive agent, induces apoptosis, inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins, inhibits blood-stage Plasmodium falciparum with IC50 of 20.3 uM, also is a small-molecule DKK1 antagonist that attenuates DKK1-mediated LRP6 sequestration, restores Wnt/β-catenin signaling.

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500 mg ￥880 In stock
1 g ￥1280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Risedronate (Risedronic acid) is a bisphosphonate and potent antiresorptive agent, induces apoptosis, inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins, inhibits blood-stage Plasmodium falciparum with IC50 of 20.3 uM, also is a small-molecule DKK1 antagonist that attenuates DKK1-mediated LRP6 sequestration, restores Wnt/β-catenin signaling.

物理化学性质&存储条件

分子量 283.11
分子式 C7H11NO7P2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1-Hydroxy-2-(pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid

参考文献

1. Manandhar S, et al. Eur J Pharmacol. 2026 May 14;1026:178971.

2. Jordao FM, et al. Antimicrob Agents Chemother. 2011 May;55(5):2026-31.

3. Fujita H, et al. Basic Clin Pharmacol Toxicol. 2011 Aug;109(2):78-84.

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