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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Proton Pump-Revaprazan hydrochloride
Revaprazan hydrochloride

Chemical Structure : Revaprazan hydrochloride

CAS No.: 178307-42-1

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Revaprazan hydrochloride (SB641257, YH-1885)

货号: PC-62891Not For Human Use, Lab Use Only.

Revaprazan hydrochloride (SB641257, YH-1885) is a potent potassium-competitive acid blocker (P-CAB) that inhibits H+,K+-ATPase in a reversible and K+-competitive manner.

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100 mg ￥1280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Revaprazan hydrochloride (SB641257, YH-1885) is a potent potassium-competitive acid blocker (P-CAB) that inhibits H+,K+-ATPase in a reversible and K+-competitive manner.
Revaprazan reduces gastric acid secretion, also exerts anti-inflammatory action against Helicobacter pylori-induced COX-2 expression by inactivating Akt signaling.

物理化学性质&存储条件

分子量 398.91
分子式 C22H24ClFN4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-fluorophenyl)-4,5-dimethyl-6-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)pyrimidin-2-amine hydrochloride

参考文献

1. Li H, et al. Drug Metab Dispos. 2001 Jan;29(1):54-9.

2. Lee JS, et al. J Clin Biochem Nutr. 2012 Sep;51(2):77-83.

3. Inatomi N, et al. Pharmacol Ther. 2016 Dec;168:12-22.

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