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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-Resiniferatoxin
Resiniferatoxin

Chemical Structure : Resiniferatoxin

CAS No.: 57444-62-9

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Resiniferatoxin ((+)-Resiniferatoxin)

货号: PC-24742Not For Human Use, Lab Use Only.

Resiniferatoxin ((+)-Resiniferatoxin) is a high affinity, selective agonist of transient receptor potential vanilloid 1 (TRPV1), binds HEK293/VR1 cells and CHO/VR1 cells with affinities of 84 and 103 pM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Resiniferatoxin ((+)-Resiniferatoxin) is a high affinity, selective agonist of transient receptor potential vanilloid 1 (TRPV1), binds HEK293/VR1 cells and CHO/VR1 cells with affinities of 84 and 103 pM, respectively.
Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period.
Resiniferatoxin induces a transient elevation in intracellular free Ca2+ concentration in hVR1-HEK293 cells with pEC50 of 6.45.
Resiniferatoxin Ca2+ mobilization from inositol 1,4,5-trisphosphate-sensitive Ca2+ stores in hVR1-HEK293 cells.
Resiniferatoxin (0.01-0.1 mg/kg; s.c.) inhibits both the osteosarcoma- and the CFA-induced hyperalgesia.

物理化学性质&存储条件

分子量 628.71
分子式 C37H40O9
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-Hydroxy-3-methoxy-[(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]benzeneacetate

参考文献

1. Szallasi A, et al. Mol Pharmacol. 1999 Sep;56(3):581-7.

2. Caterina MJ, et al. Science. 2000 Apr 14;288(5464):306-13.

3. Marshall IC, et al. Br J Pharmacol. 2003 Jan;138(1):172-6.

4. Menéndez L, et al. Neurosci Lett. 2006 Jan 23;393(1):70-3.

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