Remodelin hydrobromide |CAS:1622921-15-6 Probechem Biochemicals

Chemical Structure : Remodelin hydrobromide

CAS No.: 1622921-15-6

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Remodelin hydrobromide

货号: PC-45052Not For Human Use, Lab Use Only.

Remodelin hydrobromide is a potent inhibitor of the acetyl-transferase protein NAT10 that acetylates both histones and microtubules.

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25 mg	￥1380	In stock
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生物&药学活性

Remodelin hydrobromide is a potent inhibitor of the acetyl-transferase protein NAT10 that acetylates both histones and microtubules.
Remodelin significantly reduces the prevalence of misshapen nuclei in HGPS cells, prevents FTI-induced nuclear shape defects in normal fibroblasts and U2OS cells.
Remodelin does not affect Golgi apparatus integrity or tubulin polymer assembly, and does not cause cells to accumulate in mitosis.

物理化学性质&存储条件

分子量	363.2754
分子式	C15H15BrN4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 44 mg/mL
Chemical Name/SMILES	Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-, hydrobromide (1:1)

参考文献

1. Larrieu D, et al. Science. 2014 May 2;344(6183):527-32.

2. Mathieu J, et al. Cell Stem Cell. 2016 Jul 7;19(1):3-4.

3. Cobb AM, et al. Aging Cell. 2016 Jul 27. doi: 10.1111/acel.12506.

Remodelin hydrobromide

生物&药学活性

物理化学性质&存储条件

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Remodelin hydrobromide

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