Razuprotafib sodium (AKB-9778) | VE-PTP inhibitor | Probechem Biochemicals

Chemical Structure : Razuprotafib sodium

CAS No.: 1809275-69-1

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Razuprotafib sodium (AKB-9778 sodium, AKB9778 sodium)

货号: PC-60081Not For Human Use, Lab Use Only.

Razuprotafib sodium (AKB-9778) is a potent, selective inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP, HPTPβ) with IC50 of 17 pM.

规格	价格	库存
2 mg	￥2180	In stock
5 mg	￥3580	In stock
10 mg	￥5480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Razuprotafib sodium (AKB-9778) is a potent, selective inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP, HPTPβ) with IC50 of 17 pM.

AKB-9778 shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC50=36 pM) and HPTPγ (IC50=100 pM).

AKB-9778 activates TIE2, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK.

AKB-9778 blocks VEGF-induced leakage from dermal and retinal vessels and prevents exudative retinal detachments in double-transgenic mice.

物理化学性质&存储条件

分子量	608.68
分子式	C26H25N4NaO6S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-{(2S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-phenylpropanamido}-2-[2-(thiophen-2-yl)-1,3-thiazol-4-yl]ethyl}phenyl)sulfamic acid, sodium salt

参考文献

1. Goel S, et al. J Natl Cancer Inst. 2013 Aug 21;105(16):1188-201.

2. Shen J, et al. J Clin Invest. 2014 Oct;124(10):4564-76.

3. Amarasinghe KK, et al. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4252-6.

Razuprotafib sodium (AKB-9778 sodium, AKB9778 sodium)

生物&药学活性

物理化学性质&存储条件

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Razuprotafib sodium (AKB-9778 sodium, AKB9778 sodium)

生物&药学活性

物理化学性质&存储条件

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