Rapavir | NTCP inhibitor, HBV inhibitor | Probechem Biochemicals

Chemical Structure : Rapavir

加入收藏

Rapavir (JH-B10)

货号: PC-24441Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Rapavir (JH-B10) is a novel inhibitor of sodium taurocholate cotransporting polypeptide (NTCP) with potent anti-HBV efficacy, shows inhibitory activity against both TCA-d4 uptake and HBV infection with IC50 of 1.8 nM (TCA-d4), 63 nM (HBeAg), and 22 nM (HBV 3.5-kb RNA), respectively.
The inhibitory effect of rapavir is FKBP12-independent.
Rapavir significantly reduced intracellular HBV cccDNA and HBV RNA, along with extracellular HBeAg and HBsAg, in a concentration-dependent manner, exerts its antiviral effect during the HBV infection phase by directly blocking NTCP, rather than impacting the viral replication process.
Rapavir (2 mg/kg body weight, i.p.) demonstrated the robust anti-HBV activity in humanized liver-chimeric mice.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. He J, et al. Signal Transduct Target Ther. 2025 Apr 23;10(1):130.

Rapavir (JH-B10)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Rapavir (JH-B10)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.